Clinician's Manual on Restless Legs Syndrome by Mark J. Buchfuhrer

Author:Mark J. Buchfuhrer
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

5.3.1 Antihistamines

Older first-generation sedating antihistamines tend to worsen RLS symptoms. This includes many drugs added to combination with cold remedies and OTC sleeping pills (e.g., diphenhydramine or doxylamine). Newer second-generation nonsedating antihistamines (e.g., loratadine, desloratadine, fexofenadine) generally do not worsen RLS. For treating rhinitis in patients with RLS, safe alternatives to using antihistamines include corticosteroid- and cromolyn-based nasal sprays and montelukast (an anti-inflammatory).

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